The explosive spread of the Zika virus—which before 2015 was considered little more than a travel medicine trivia question—in South America has been declared a public health emergency of international concern because of its association with severe complications such as microcephaly and Guillain-Barré syndrome. This outbreak and the myriad public health actions it has prompted are occurring in a very fluid context in which new facts about the virus and its trajectory are being discovered almost daily. Understanding what is known, and the important questions that remain to be answered, is essential to optimize response to this emerging infectious disease.
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