One of the common ways that many infectious diseases cause morbidity and mortality is the sepsis cascade. Virtually all microbes, in the correct context, can trigger this cascade, with varying degrees of likelihood. This includes the Aedes mosquito–transmitted virus chikungunya. While many clinicians are aware of chikungunya’s spread and its cardinal symptoms, fewer are probably aware of its propensity to cause sepsis and septic shock, as recently documented in a study published in Emerging Infectious Diseases.
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