During July 2015–May 2016, a mumps outbreak occurred at the University of Iowa, which is located in Johnson County (1). A total of 301 cases of mumps were diagnosed among students. To characterize the outbreak, the Johnson County Public Health Department, the Iowa Department of Public Health, and the University of Iowa, with assistance from CDC, conducted an investigation through telephone interviews, medical chart abstractions, and review of immunization records. Among 287 (95%) students with mumps for whom clinical information was available, 20 (7%) patients with complications were identified (16 self-reported and four clinician-diagnosed). The 20 cases included 15 (5%) cases of orchitis, three (1%) of transient hearing loss, two of mastitis, and one of meningitis (one patient had both orchitis and transient hearing loss). All 20 patients had documentation of receipt of at least 2 doses of measles-mumps-rubella vaccine. Because data are limited regarding the presentation and clinical course of mumps complications in persons who have received 2 doses of mumps-containing vaccine, three illustrative cases of complications (orchitis, transient hearing loss, and meningitis) in students with mumps are presented.
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